All Ice Packs: Store in the freezer for 2 hours to freeze gel. Do not put in microwave. This ice pack is specifically developed for cold therapy. This is reusable. Do not apply directly on the skin as that can cause frostbite. Apply with towel, elastic wrap, or shrink-wrap. Apply after physical activity to the area of pain. Two to three times per day, and 20-30 minutes per session.